Role of epicardial adipose tissue in the development of cardiovascular diseases

Epicardial adipose tissue (EAT) has unique properties due to its special anatomical structure, thermoregulation, and metabolic activity. Dysregulated EAT provokes the synthesis of pro-inflammatory cytokines, disorders in metabolism fats glucose, as well contributes fatty degeneration myocardium heart failure development. may serve a risk factor biomarker for cardiovascular diseases, is also potential therapeutic target. The purpose this review was highlight current research data on EAT, secreted adipokines, their effect target metabolism, systematize relationship between diseases. In particular, function, role failure, atrial fibrillation, prognostic value various microRNAs determined are highlighted.